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Oxymorphone is an opioid medication used to treat moderate to severe pain. The extended-release form of oxymorphone is for around-the-clock treatment of pain and should not be used on an as-needed basis for pain. Oxymorphone may also be used for purposes not listed in this medication guide. Oxymorphone, sold under the brand names Numorphan among others (Opana), is a powerful semi-synthetic opioid analgesic (painkiller). Pain relief after injection begins after about 5–10 minutes and 15–30 minutes after rectal administration, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets.
Oxymorphone Immediate Release is indicated for the relief of moderate to severe pain, such as treatment of acute post-surgical pain. For any chronic treatment of pain, clinicians should only consider long term use if there are significant clinical benefits to the patient’s therapy that outweigh the risks. The first-line treatment choices for chronic pain are non-pharmacological and non-opioid agents.
Oxymorphone extended-release tablets are indicated for the management of chronic pain and only for people already on a regular schedule of strong opioids for a prolonged period. Immediate-release oxymorphone tablets are recommended for breakthrough pain for people on the extended-release version. Compared to other opioids, oxymorphone has similar pain-relieving efficacy.
Common side effects of oxymorphone include constipation, nausea, vomiting, somnolence, dizziness, itching, dry mouth, and sweating. Less common side effects include loss of appetite, nervousness, abdominal pain, diarrhea, urine retention, dyspnea, and hiccups.
In high doses, or in some persons not tolerant to opioids, oxymorphone can cause shallow breathing, slowed heart rate, cold/clammy skin, pauses in breathing, low blood pressure, constricted pupils, circulatory collapse, respiratory arrest, and death.
oxymorphone overdose has also been described to cause spinal cord infarction in high doses and ischemic damage to the brain, due to prolonged hypoxia from suppressed breathing.
The symptoms of oxymorphone withdrawal, as with other opioids, may include “anxiety, panic attack, nausea, insomnia, muscle pain, muscle weakness, fevers, and other flu-like symptoms”.
Chronic use of oxymorphone (particularly with higher doses) often causes concurrent hypogonadism or hormone imbalance.
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